Points for suggesting a matchup on this board that I haven’t seen before. Kara has more experience, but Xiomara’s healing ability is tough to contend with. I could see this going either way, depending on the circumstances.

Similarly with Lobo, it’s all really up to writer.

Hand-to-hand? Crush or a draw.

Starting from afar? Supergirl with her superspeed flight, heat vision or super-breath.

Crush because Supergirl is weak with Argoanite.