Many new titles and/or runs on pre-existing titles have started with Infinite Frontier, so I imagine you’d have some jumping-in points to choose from. Remember that there’s typically no need to “start at the beginning” for any character or team. So it’s perfectly fine to start a new comic title, and if there are any blanks that need filled, you can research the context you want to know or otherwise fill in those holes with additional readings as you move forward. Although, I imagine most of the titles are going to be accessible, as I believe the Infinite Frontier banner is a marketing move designed for new readers to jump in.