The 16th Century includes all events that took place from January 1st of year 1501 to December 31st of 1600.
- The time-displaced Super Sons were captured by Vandal Savage, Felix Faust, and Faust's apprentice Rora. They attempted to use their knowledge of the future to aid in conquest, but the pair escaped back to the 21st Century.
- Suleiman the Magnificent and Merlin hid an enchanted scimitar with The Book of Eternity to prevent it from being fallen into the hands of Etrigan.
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