Haven't you learned by now, Superman? There is no Emil Hamilton, not anymore! For you and your friends-- --There is only Ruin! 
- — Ruin
Adventures of Superman #646 is an issue of the series Adventures of Superman (Volume 1) with a cover date of January, 2006. It was published on November 23, 2005.
Synopsis for "Rack & Ruin, Part I of II"
Clark Kent discovers a confused and amnesic Mister Mxyzptlk who is unable to return to the fifth dimension. They go out for coffee together and eventually, Clark deduces the true identity of Ruin.
Lois Lane meets with Wonder Woman (who is being detained for the murder of Maxwell Lord) to investigate the connection between Checkmate and the sniper that shot her. Following the leads, she blackmails a Checkmate agent into revealing that the sniper was Sasha Bordeaux, who confesses that she had been instructed to do so by Max Lord.
Meanwhile Lupé Leocadio-Escudero invades what she believes is Ruin's hideout to find a hostage Lana Lang and a disguised Pete Ross just as Superman confronts the real Ruin.
Appearing in "Rack & Ruin, Part I of II"
Featured Characters:
Supporting Characters:
- Perry White (Behind the scenes) (Phone call only)
- Lana Lang
- Lois Lane
- S.C.U.
- Pete Ross
Antagonists:
- Mister Mxyzptlk (Apparent Death)
- Ruin
Other Characters:
- Diner Waitress (Unnamed) (Cameo) (Single appearance)
- Clark Peter Ross
- Sasha Bordeaux (as a cyborg)
- Wonder Woman
- Jonah McCarthy
- Checkmate (Mentioned only)
- Black King (Mentioned only)
- Metropolis Police Department (Mentioned only)
- Lex Luthor (Mentioned only)
- Zatanna (Mentioned only)
- Brother Eye (Mentioned only)
- OMAC (Mentioned only)
Locations:
- Fifth Dimension (Mentioned only)
- Phantom Zone (Mentioned only)
- Metropolis
- Kodiak Diner
- Ross' Residence
- Daily Planet
- Outskirts
- Ruin's Hideout
- The Netherlands
- The Hague
- International Crime Court Detention Center
- The Hague
- Switzerland
- Zürich
- Restaurant (Unnamed)
- Zürich
Items:
- Daily Planet Newspaper
- Gold Kryptonite
Vehicles:
- None
Concepts:
Notes
- This issue is reprinted in the Superman: Ruin Revealed trade paperback.
Trivia
- Page 3 panel 1 is a homage of the painting Nighthawks by Edward Hopper.