The Brain and his assistant Monsieur Mallah are behind an experiment to use mind-control collars on India's wildlife, which he had enhanced into enlarged monsters using Kobra Venom. The Team went to investigate and Captain Marvel was captured, Brain tried to surgically remove Captain Marvel's brain to see what effects "the wisdom of Solomon" had on it. The Team defeats the mutated animals by removing their mind-control collars. The team then manages to find a way into Brain's lair with the help of Wolf and Mr. Tawny and defeat them, but Brain and Monsieur Mallah end up getting away. It is later revealed that Brain is L-6 of The Light.
- This version of the character is exclusive to the continuity of the television series Young Justice and its tie-in comic book series. It is an adaptation of the Brain. The original character was created by Arnold Drake and Bruno Premiani and first appeared in Doom Patrol #86.
- The Brain was voiced by Nolan North for the episode "Drop Zone" and by Corey Burton for later appearances.
- 17 Appearances of Brain (Earth-16)
- 2 Images featuring Brain (Earth-16)
- Quotations by or about Brain (Earth-16)
- Character Gallery: Brain (Earth-16)