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Crazy Jane is a member of the Doom Patrol and the dominant alternate personality of Kay Challis, a girl who developed dissociative identity disorder after being abused by her father. As a result of exposure to the Dominators' "gene bomb," Challis became a metahuman, with each of her 64 alternate personalities having a different super-power and residing in a place with her psyche known as "the Underground". Her Prime Earth counterpart has a new personality named "The Chief", who led the Doom Patrol as a replacement for Niles Caulder.

Kay/Jane from the Doom Patrol tv series eventually managed to merge with all of her personalities in one single being named Kaleidoscope.

Crazy Jane was created by Grant Morrison and Richard Case, first appearing in Doom Patrol (Volume 2) #19 (1989).

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