The D.E.O. (Department of Extranormal Operations) is a U.S. government agency which investigates and processes metahuman activities and persons and is charged with facilitating methods of counteracting metahuman threats. It's headed by former Infinity, Inc. member, Mister Bones. Its headquarters is New York and they report to the US Secretary of Metahuman Affairs, which was originally Amanda Waller.
The D.E.O. first came to light in Gotham City when a Dr. Peter Malley merged with a sample from Clayface Cassius Payne to form into Clay-Thing. As it happened, Cameron Chase, on her way to visit her sister in Gotham before her very first D.E.O. assignment. Chase was contacted by an Agent Barrett and given the assignment of tracking Malley down. Naturally she crossed paths with the Batman, and the two (with Chase's unintentional use of her own metahuman powers), captured him.
The D.E.O. also runs various facilities designed to house, train and study metahumans. One of their specimens, Greta Hayes, escaped, in which the D.E.O. called upon the newly formed Young Justice to recapture her. The team eventually learned that Hayes had been mistreated while in their possession and they let her go free. Hayes eventually joined their group as the Secret and led them back to the D.E.O. "orphanage" to free others like her.
When President Lex Luthor's appointed his cabinet, Amanda Waller was charged with overseeing Bones and the D.E.O. Bones eventually came to odds with his former colleagues in the Justice Society of America when the D.E.O. requested the team's aid in eliminating Kobra from Blackhawk Island. Following the mission, the JSA discovered that Blackhawk Express operation on the island was owned by the D.E.O. The JSA felt as though they were duped into doing the agency's dirty work, and left in anger. Bones had again been ordered to enlist the JSA's help by an unrevealed superior. He demonstrated reluctance to further betray his former colleagues, but is indebted to the D.E.O.
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