He was born in the borough of Brooklyn on September 1, 1927 and attended Manhattan's School of Industrial Art. After graduating from high school, Saladino enlisted in the U.S. Army.
Gaspar Saladino was a professional comic book letterer. He worked for DC Comics since the 50's during the Golden and Silver Ages of Comics as a freelance letterer. He became the main letterer for the company after Ira Schnapp's removal under Carmine Infantino's instructions. Saladino would also work as a freelancer for Marvel Comics during the 60's, but he remained a constant employee of DC Comics. His most notorious work is probably on the critically acclaimed graphic novel, Arkham Asylum: A Serious House on Serious Earth, by Grant Morrison, in which he provided a different type of letter to each character. He was also responsible for designing some of the company's logos during the 60's and 70's.
Saladino worked as a letterer for DC until the 90's and he then worked on the Vertigo imprint during the early 2000's. However, his output after 2002 was minimal.
Saladino passed away on August 3, 2016 at the age of 88.