In the 1930s, debutante Dian Belmont and her best friend Catherine van der Meer enjoyed going to the jazz clubs of Harlem.
Several years ago, the New Teen Titans went to Harlem to rescue a kidnapped model named Angela Dove from the clutches of mobster Phil Cerullo. Cerullo had kidnapped Angela in order to muscle her boyfriend Jason Silver into not testifying against him at his trial. The Titans burst through the wall of the building and took out Cerullo's gunmen. Starfire stunned the gangster with a starbolt.
Harlem is also where reformed criminal Ronald Evers established the First Church of Anti-Technocracy. A former cyborg, Evers turned to spirituality and developed his following due to his past conflicts with childhood friend Victor Stone.