When Selina was taken to prison, Isis ran away looking for her. Isis got lost and was found on the streets by Doctor Milo, who used the cat for one of his twisted experiments. Selina found Isis but the cat has been infected with a virus that made her more aggressive and contagious to people. Selina feared she had lost Isis forever but Batman delivered Isis back to her, completely cured and safe.
- Isis was voiced by Frank Welker for most of the character's appearances. Dee Bradley Baker voiced Isis for the animated web series Gotham Girls.
- 13 Appearances of Isis (DCAU)
- 3 Images featuring Isis (DCAU)
- Quotations by or about Isis (DCAU)
- Character Gallery: Isis (DCAU)