Jokers are people in Gotham City who, for some reason, have suddenly become criminally insane.
Dealing with Jokers is considered a normal part of life in Gotham.
Hal Jordan became Jokered and killed himself with his Green Lantern Ring. Batman has a policy of killing superheroes in Gotham on sight, before they can be Jokered. Jason Todd's business Jason Todd Tires sells "Todd-Tire-Taze", a device that electrocutes Jokers who try to steal tires.
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