Karla was a gifted aerialist who married Rick Grayson and joined him and his brother in the aerialist performing group the Flying Graysons. She had one son with her husband who himself became an aerialist and became a member of the Flying Graysons.
On April 1, 2006  while performing with Haley's Circus she was murdered along with her son John, her brother-in-law John and her brother-in-law's wife Mary through an act of sabotage by men working under the mob boss Tony Zucco.
- 1 Appearances of Karla Grayson (Earth-16)
- 1 Images featuring Karla Grayson (Earth-16)
- Quotations by or about Karla Grayson (Earth-16)
- Character Gallery: Karla Grayson (Earth-16)