Created under unknown circumstances by unknown parties, the only samples of the drug encountered thus far were on a submarine which was accidentally beached in the China Sea on a small island of no importance.
Decades later, they and the paperwork of their creation were desperately sought by Anthony Ivo, a scientist who wanted to create super-cures, but was willing to torture, blackmail and bully to get his end. The Mirakuru was initially used on one person - Slade Wilson, who demonstrated murderous mood swings. This led Oliver Queen to destroy the Mirakuru and the paperwork, to the horror of Ivo.
However, five years later Wilson had amassed resources, and came to Starling City planning to kill Oliver Queen. To that end he hired chemists to extract Mirakuru from samples of his own mutated blood, then used it to empower agents as part of his scheme.
In the course of the scheme, Queen and his allies created a counter-serum, which bonds with Mirakuru in the system and neutralizes it. With the depowering of Wilson and the death of many of his underlings, the threat was ended.
- "Mirakuru" is the Japanese pronunciation of miracle
- Its name being derived from miracle, is most likely derived from "Miraclo", the drug used by Hourman, whose formula was later synthesized into the steroid "Venom" used by the supervillain Bane.
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