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Pamela Isley was sent to Arkham Asylum for refusing to act as other women did in 1900 and believing that women were being deprived of the rights they deserved. Before her arrest, she also encountered The Joker and was angered by his attempts to woo her. She also detested being addressed as "Miss Isley" and preferred to be called "Poison Ivy".

While Jonathan Crane believed that Poison Ivy's rants on women being second-class citizens proved that she was insane, Bruce Wayne agreed with her assertions and believed that she was wrongly imprisoned.

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