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Y: The Last Man is a comic book series written by Brian K. Vaughan and published under the DC Comics Vertigo imprint. The series centers around the sole surviving male human after the spontaneous, simultaneous death of every male mammal on Earth.

The series starts in the summer of 2002, when Earth is struck by a pandemic plague of unknown origin. This plague destroyed every mammal with a Y chromosome, including spermatosa and unborn children. Referred to as "gendercide", the plague exterminated 48% of the global population, approximately 2.9 billion men.[1] Two male mammals survived: a young man from Brooklyn named Yorick Brown & his pet Capuchin monkey Ampersand.

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